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Year : 2016  |  Volume : 2  |  Issue : 1  |  Page : 48-49

Psoriasis versus psoriasiform drug eruption


1 Department of Dermatology, Government Medical College and Hospital, Mumbai, Maharashtra, India
2 Department of Dermatology, Seth G. S. Medical College, KEM Hospital, Mumbai, Maharashtra, India
3 Department of Dermatology, NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital, Nagpur, Maharashtra, India

Date of Web Publication15-Jun-2016

Correspondence Address:
Kinjal Deepak Rambhia
House No. 574, Mukundraj Lane, Walker Road, Mahal, Nagpur - 440 032, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2455-3972.184083

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How to cite this article:
Rambhia KD, Gulati AS, Pande S. Psoriasis versus psoriasiform drug eruption. Indian J Drugs Dermatol 2016;2:48-9

How to cite this URL:
Rambhia KD, Gulati AS, Pande S. Psoriasis versus psoriasiform drug eruption. Indian J Drugs Dermatol [serial online] 2016 [cited 2020 Jan 18];2:48-9. Available from: http://www.ijdd.in/text.asp?2016/2/1/48/184083




  Summary Top


Psoriasis is a chronic relapsing and remitting autoimmune condition which presents as erythematous, well-defined plaques with silvery white scales. The lesions commonly occur on the extensor aspects of the limbs and trunk. There may be associated scalp, palms, soles, and nail involvement. Psoriasiform drug eruption is defined as heterogeneous group of disorders characterized by clinical or histological resemblance to psoriasis at some points during a disease. Drugs may be responsible for precipitation of psoriasis de novo, exacerbation of preexisting psoriasis, and development of treatment-resistant psoriasis. Clinically, drug-provoked psoriasis can present as generalized plaque psoriasis, palmoplantar pustulosis, or erythroderma. Histologically, there are parakeratosis, presence of granular layer, psoriasiform epidermal hyperplasia, but no evidence of suprapapillary thinning or dilated capillaries. They may resolve after withdrawal of the offending drug. Some features which are helpful in distinguishing psoriasis from psoriasiform drug eruption are enlisted in [Table 1] [Figure 1] and [Figure 2].
Table 1: Psoriasis versus psoriasiform drug eruption

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Figure 1: Well-defined erythematous scaly plaques over the bilateral lower extremities in psoriasis

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Figure 2: Histopathology of psoriasis showing parakeratosis, reduction in the granular layer, regular elongation of rete ridges, and dilated vasculature in the papillary dermis.

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Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1]



 

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