|Year : 2016 | Volume
| Issue : 2 | Page : 115-116
Drug-induced fever versus infection-induced fever
Sagar Jugtawat, Bhagyashri Daulatabadkar, Sushil Pande
Department of Dermatology, NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital, Nagpur, Maharashtra, India
|Date of Web Publication||20-Dec-2016|
Department of Dermatology, NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital, Nagpur, Maharashtra
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Jugtawat S, Daulatabadkar B, Pande S. Drug-induced fever versus infection-induced fever. Indian J Drugs Dermatol 2016;2:115-6
|How to cite this URL:|
Jugtawat S, Daulatabadkar B, Pande S. Drug-induced fever versus infection-induced fever. Indian J Drugs Dermatol [serial online] 2016 [cited 2020 Aug 5];2:115-6. Available from: http://www.ijdd.in/text.asp?2016/2/2/115/196224
Drug-induced fever is a disorder characterized by a febrile response coinciding temporally with the administration of a drug in the absence of underlying conditions that can be responsible for the fever. Fever is a common symptom in day-to-day clinical practice, and a large number of indoor admissions are attributed to patients suffering from fever. Many of these patients are also put on anti-infective agents such as antibiotics, antivirals, antifungals, or antiparasitic drugs, considering infections as the predominant cause of fever. However, drugs initiated for the treatment of underlying diseases can be a cause of fever in such setting. It is a diagnostic dilemma to differentiate between infection-induced fever and drug-induced fever. The following table enlists differences between the two so as to help physician to differentiate between the two to take appropriate decisions. The distinction is especially important with regard to drug discontinuation and decision regarding the initiation of corticosteroid treatment [Table 1].
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| References|| |
Hanson MA. Drug fever. Remember to consider it in diagnosis. Postgrad Med 1991;89:167-70, 173.
Roush MK, Nelson KM. Understanding drug-induced febrile reactions. Am Pharm 1993;NS33:39-42.
Tabor PA. Drug-induced fever. Drug Intell Clin Pharm 1986;20:413-20.
Cluff LE, Johnson J 3 rd
. Drug fever. Prog Allergy 1964;8:149-94.
Johnson DH, Cunha BA. Drug fever. Infect Dis Clin North Am 1996;10:85-91.
Tisdale JE, Miller DA. Drug-induced Diseases: Prevention, Detection, and Management. Bethesda, MD: American Society of Health-Systems Pharmacists; 2005.
Mackowiak PA, LeMaistre CF. Drug fever: A critical appraisal of conventional concepts. An analysis of 51 episodes in two Dallas hospitals and 97 episodes reported in the English literature. Ann Intern Med 1987;106:728-33.
Lipsky BA, Hirschmann JV. Drug fever. JAMA 1981;245:851-4.
Oizumi K, Onuma K, Watanabe A, Motomiya M. Clinical study of drug fever induced by parenteral administration of antibiotics. Tohoku J Exp Med 1989;159:45-56.
Sudhir U, Venkatachalaiah RK, Kumar TA, Rao MY, Kempegowda P. Significance of serum procalcitonin in sepsis. Indian J Crit Care Med 2011;15:1-5.