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MANAGING A SIDE EFFECT
Year : 2019  |  Volume : 5  |  Issue : 1  |  Page : 66-71

Managing a side effect: Cyclophosphamide-induced hemorrhagic cystitis


Department of Dermatology, KLE Academy of Higher Education and Research, JNMC, Belagavi, Karnataka, India

Correspondence Address:
Dr. Bhavana Ravindra Doshi
Department of Dermatology, KLE Academy of Higher Education and Research, JNMC, Belagavi - 590 010, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdd.ijdd_31_19

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Cyclophosphamide is a nonphase-specific cytotoxic agent that can kill cells at any phase of the cell cycle. The drug is metabolized by hepatic cytochrome P450 microsomal enzymes, which results in the formation of the active metabolites phosphoramide mustard and acrolein. It is the acrolein which is responsible for hemorrhagic cystitis as a complication of cyclophosphamide therapy. An early diagnosis and prompt management holds the key in its management.


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