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MANAGING A SIDE EFFECT
Year : 2020  |  Volume : 6  |  Issue : 1  |  Page : 49-52

Cardiac side effect of rituximab


1 Department of Cardiology, Venereology and Leprosy, J. N. Medical College, Belagavi, Karnataka, India
2 Department of Dermatology, Venereology and Leprosy, J. N. Medical College, Belagavi, Karnataka, India

Correspondence Address:
Dr. Snehal Balvant Lunge
Assistant Professor, Department of Dermatology, Venereology and Leprosy, J. N. Medical College, Belagavi - 590 010, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdd.ijdd_64_19

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Rituximab is an anti-CD20 monoclonal antibody frequently used for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, and anti-neutrophilic cytoplasmic antibody-associated vasculitis. In addition, rituximab has recently been increasingly used as an off-label treatment in a number of inflammatory and systemic autoimmune diseases. Its side effect profile includes infusion-related reactions and adverse cardiac effects such as arrhythmia and angina, particularly in patients with prior history of cardiovascular diseases. However, its detailed cardiotoxicity profile, effects on cardiac function, and its management are not well described in the literature. As the utility of rituximab expands, primary physicians, intensivist, dermatologist who use drug should be made of these serious cardiovascular adverse effect.


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