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CASE REPORT
Year : 2020  |  Volume : 6  |  Issue : 1  |  Page : 28-31

Treatment of post kala-azar dermal leishmaniasis with fungisome – A novel Indian liposomal amphotericin B


1 Department of Dermatology, Venereology and Leprosy, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India
2 Department of National Chair Clinical Pharmacology, ICMR, Delhi, India

Correspondence Address:
Dr. Nilima A Kshirsagar
Department of National Chair Clinical Pharmacology, ICMR, Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdd.ijdd_55_19

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Post kala-azar dermal leishmaniasis (PKDL) is a late cutaneous manifestation of visceral leishmaniasis (VL), though it can occur without a history of visceral disease. The diagnosis and treatment of PKDL is important as cases of PKDL have been known to cause outbreaks of VL. We report a case of PKDL from an area with low endemicity of VL and has presented with PKDL without VL. Due to poor tolerance to conventional amphotericin B (CAmB), he was successfully treated with Fungisome™ – Indian liposomal amphotericin B (LAmB). We want to emphasize on the successful treatment of PKDL with Fungisome™ – an Indian LAmB. This is a first such case of PKDL being treated with LAmB (Fungisome™), developed jointly by the Department of Clinical Pharmacology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, and the Department of Biochemistry, Delhi University with funding from the Department of Biotechnology. Translational research and commercialization was done by Lifecare Innovations, India.


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