• Users Online: 295
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2023  |  Volume : 9  |  Issue : 1  |  Page : 21-27

Efficacy and safety of rituximab in treatment of systemic sclerosis: A retrospective study

Department of Skin & VD, Patna Medical College and Hospital, Patna, Bihar, India

Correspondence Address:
Anupama Singh
Department of Skin & VD, Patna Medical College and Hospital, Patna 800004, Bihar
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijdd.ijdd_16_22

Rights and Permissions

Background: Conventional treatment of systemic sclerosis with drugs for symptom control and broad-spectrum immunosuppression has remained unsatisfactory. Depletion of B-lymphocytes, which are a crucial element in pathogenesis, with rituximab (RTX) has produced encouraging results. Objective: This study aimed to retrospectively analyze the safety and efficacy of RTX in systemic sclerosis. Materials and Methods: Baseline, 6- and 12-month follow-up data of 13 systemic sclerosis (11 diffuse and 2 limited) patients (10 adult and 3 adolescent) who received 4 infusions of 500 mg RTX at 2-weekly intervals was accessed and retrospectively analyzed. Results: Modified Rodnan Skin Score progressively improved from a baseline of 22.2 ± 7.97 to 17.7 ± 7.95 at 6 months (P < 0.05) and 14 ± 7.12 at 12 months (P < 0.05 vs. baseline and 6-month), and mouth opening increased from 2.23 ± 0.44 fingers to 3.5 ± 0.52 fingers at 12 months (P < 0.05). Pruritus and melanoderma improved in all those affected. Raynaud’s phenomenon improved in 12/13, whereas digital ulcers improved significantly in 9/12 patients. Arthritis remitted in the six affected patients, and percentage predicted forced vital capacity improved from a baseline of 70 ± 9.09 to 76.54 ± 7.5 at 12 months (P < 0.05). There were no serious adverse effects. Conclusion: RTX showed good outcome in cutaneous, joint, and pulmonary features of systemic sclerosis without any significant adverse event.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded33    
    Comments [Add]    

Recommend this journal