Indian Journal of Drugs in Dermatology

MANAGING A SIDE EFFECT
Year
: 2019  |  Volume : 5  |  Issue : 1  |  Page : 66--71

Managing a side effect: Cyclophosphamide-induced hemorrhagic cystitis


Bhavana Ravindra Doshi, Vijaya Veeranna Sajjan, BS Manjunathswamy 
 Department of Dermatology, KLE Academy of Higher Education and Research, JNMC, Belagavi, Karnataka, India

Correspondence Address:
Dr. Bhavana Ravindra Doshi
Department of Dermatology, KLE Academy of Higher Education and Research, JNMC, Belagavi - 590 010, Karnataka
India

Cyclophosphamide is a nonphase-specific cytotoxic agent that can kill cells at any phase of the cell cycle. The drug is metabolized by hepatic cytochrome P450 microsomal enzymes, which results in the formation of the active metabolites phosphoramide mustard and acrolein. It is the acrolein which is responsible for hemorrhagic cystitis as a complication of cyclophosphamide therapy. An early diagnosis and prompt management holds the key in its management.


How to cite this article:
Doshi BR, Sajjan VV, Manjunathswamy B S. Managing a side effect: Cyclophosphamide-induced hemorrhagic cystitis.Indian J Drugs Dermatol 2019;5:66-71


How to cite this URL:
Doshi BR, Sajjan VV, Manjunathswamy B S. Managing a side effect: Cyclophosphamide-induced hemorrhagic cystitis. Indian J Drugs Dermatol [serial online] 2019 [cited 2020 Oct 28 ];5:66-71
Available from: https://www.ijdd.in/article.asp?issn=2455-3972;year=2019;volume=5;issue=1;spage=66;epage=71;aulast=Doshi;type=0