Indian Journal of Drugs in Dermatology

BRIEF REPORT
Year
: 2020  |  Volume : 6  |  Issue : 2  |  Page : 81--84

Safety and efficacy of one week oral steroid therapy in the treatment of common eczemas: An open label randomized controlled pilot study


Vikrant Abhay Saoji1, Arun L Bhat2 
1 Department of Dermatology, JNMC, Wardha, Maharashtra, India
2 Dr Saoji's Skin Clinic, Nagpur, Maharashtra, India

Correspondence Address:
Vikrant Abhay Saoji
22, Dandige Layout, Shankar Nagar, Nagpur - 440 010, Maharashtra
India

Introduction: Oral steroids are not commonly used because of fear of side effects. A study was conducted to find out if a short course of 1 week of oral steroid without tapering is effective and safe for the treatment of common eczemas. Materials and Methods: Patients with common eczemas were included in the study. There were five groups. One group each received tablet prednisolone 15 mg morning and 10 mg after dinner for 7 days, tablet methylprednisolone 16 mg morning and 8 mg night for 7 days, and tablet betamethasone 2 mg morning and 1 mg night for 7 days. One group received tablet betamethasone 3 mg once a day as a single morning dose for 7 days and the last group received tablet deflazacort 18 mg morning and 12 mg night for 7 days only. All the patients also received topical clobetasol propionate cream for 1 month. However, the maximum permissible amount of topical clobetasol propionate was 30 g in a month. Basal serum cortisol at 8 am along with ACTH stimulation test was carried out in all the patients on day 10th. The tests were repeated on 30th day if negative on day 10th. Results: In all groups, rapid improvement was seen at visit 2, which further continued at visit 3. No suppressive effect on hypothalamic–pituitary–adrenal (HPA) axis was seen. Conclusion: A short course of oral steroid of 25 mg of prednisolone equivalent for a period of 7 days was found to be effective and safe, and 7 days of oral steroids do not need tapering.


How to cite this article:
Saoji VA, Bhat AL. Safety and efficacy of one week oral steroid therapy in the treatment of common eczemas: An open label randomized controlled pilot study.Indian J Drugs Dermatol 2020;6:81-84


How to cite this URL:
Saoji VA, Bhat AL. Safety and efficacy of one week oral steroid therapy in the treatment of common eczemas: An open label randomized controlled pilot study. Indian J Drugs Dermatol [serial online] 2020 [cited 2021 Jan 20 ];6:81-84
Available from: https://www.ijdd.in/article.asp?issn=2455-3972;year=2020;volume=6;issue=2;spage=81;epage=84;aulast=Saoji;type=0