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  Citation statistics : Table of Contents
   2018| January-June  | Volume 4 | Issue 1  
    Online since July 10, 2018

 
 
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REVIEW ARTICLE
Bilastine: A novel antihistamine
Jeet Gandhi, Kiran Godse, Gauri Godse
January-June 2018, 4(1):3-6
DOI:10.4103/ijdd.ijdd_12_18  
Bilastine is a new second generation H1-antihistamine approved for the symptomatic treatment of allergic rhinitis (AR) and chronic urticaria (CU) in patients older than 12 years of age. AR and urticaria are very common clinical conditions that represent one of the most frequent reasons for a patient to visit their general practitioner or allergist or dermatologist. Bilastine, with its efficacy and safety profile epitomizes the evolution of research on antihistamines.
  6 30,952 1,665
ORIGINAL ARTICLES
Use of over-the-counter topical medications in dermatophytosis: A cross-sectional, single-center, pilot study from a tertiary care hospital
Rajeshwari Dabas, Manasa Shettisara Janney, Radhakrishnan Subramaniyan, Sandeep Arora, V Sandeep Lal, Navya Donaparthi
January-June 2018, 4(1):13-17
DOI:10.4103/ijdd.ijdd_5_18  
Background: Dermatophytosis is a common, superficial fungal infection of the skin. In developing countries like India, casual attitude toward seeking medical attention and lax drug control policies lead to indiscriminate use of irrational over-the-counter (OTC) medications. Studies on OTC topical medication abuse in dermatophytosis are lacking despite its frequent occurrence. Aims: To assess the magnitude of OTC topical medication use in dermatophytosis by studying the demographic variables, source of prescription, and their adverse effects. Materials and Methods: This cross-sectional, observational, questionnaire-based pilot study was carried out in a tertiary care center. One hundred consecutive, mycologically confirmed dermatophytosis patients were questioned about the use of OTC medications and examined for adverse effects of the preparations used. Results were documented in a predesigned pro forma and the data were expressed in terms of means and proportions. Results: The study population consisted of 75 males and 25 females. Tinea cruris was the most common pattern observed. Only 32% of the patients consulted a dermatologist on developing a rash, whereas the majority (68%) used medicines suggested by others. Clobetasol-based preparations were commonly misused, and 63.23% of the study population experienced adverse effects. Furthermore, majority (89%) of the study population were unaware of steroids and their adverse effects. Conclusions: The growing threat of OTC drug abuse in India is evident from this study. Stringent drug control policies and awareness of adverse effects of OTC topical medication abuse are truly the need of the hour to control this menace.
  4 7,669 301
CASE REPORTS
Efficacy of doxycycline monotherapy in treating rhinoscleroma
Mithali Jage, Kinjal Deepak Rambhia, Uday S Khopkar
January-June 2018, 4(1):23-25
DOI:10.4103/ijdd.ijdd_32_17  
Rhinoscleroma, also known as Mikulicz disease, is a chronic granulomatous infection of the nasopharyngeal nucosa causing disfigurement and debilitation. A 27-year-old male presented with nasal mass and obstruction. Histopathology revealed dense, diffuse, mixed inflammatory infiltrate consisting of neutrophils, lymphocytes, plasma cells, and foamy macrophages. Mikulicz cells which are foamy macrophages containing filamentous, granular, and fragmented bacilli were seen. The patient was diagnosed as rhinoscleroma and was started on capsule doxycycline 100 mg twice daily. After 6 weeks, marked improvement in the lesions and symptoms was noticed.
  2 5,237 130
EDITORIAL
Omalizumab in the treatment of chronic urticaria
Kiran Godse
January-June 2018, 4(1):1-2
DOI:10.4103/ijdd.ijdd_19_18  
  2 10,243 338
LETTERS TO EDITOR
Good response to oral acitretin monotherapy in a case of verrucous carcinoma of sole
Rameshwar Gutte, Bhushan Madke
January-June 2018, 4(1):29-30
DOI:10.4103/ijdd.ijdd_14_17  
  1 3,061 59
Symmetrical drug related intertriginous and flexural exanthema after ranitidine therapy: A probable causal association in an 18-year-old girl
Nidhi Yadav, Sumit Kar, Varsha Verma, Komal Ramteke
January-June 2018, 4(1):34-36
DOI:10.4103/ijdd.ijdd_33_17  
  1 3,763 79
BRIEF REPORT
Role of omalizumab in refractory chronic spontaneous urticaria: A single referral center experience
Gautam Kumar Singh, Manas Chatterjee, Rajesh Verma
January-June 2018, 4(1):18-22
DOI:10.4103/ijdd.ijdd_2_18  
Background: Multiple evidence have shown that omalizumab, a subcutaneous (SC) anti-IgE monoclonal antibody, is highly effective for the treatment of chronic spontaneous urticaria (CSU). Objective: The objective is to evaluate the safety and efficacy of omalizumab administered 300 mg SC 1st month followed by 150 mg every month for another 5 months in cases of refractory CSU in a routine clinical setting. Materials and Methods: This was open-label, prospective, pilot study to know the efficacy and safety profile of omalizumab administered 300 mg SC first 1st month followed by 150 mg every month for another five 5 months in refractory CSU. The study was conducted at tertiary center in routine clinical setting. The primary efficacy evaluation was a change in Urticaria Activity Score-7 (UAS-7) and Urticaria Control Test (UCT) from baseline. Results: A total of 13 patients (7 females and 6 males) were enrolled in the study with the mean age of 35 years, having CSU from the mean duration of 3.15 years. Mean UAS-7 of patients decreased from 31.62 at baseline to 6.85 after the first dose of omalizumab treatment. This further reduced to 2.31 after 6 months (P = 0.001). Mean UCT increased from 4.46 at baseline to 13.92 after 1 month and further increased to 14.85 after 6 months (P = 0.001). A total of 11 patients (84.6%) achieved complete remission. Conclusion: Injection omalizumab is safe and highly effective therapy for refractory CSU in the routine clinical setting. It can be made cost effective without compromising the efficacy in resource-poor country of Indian subcontinent if barring first dose other can be halved of recommended dose. However, small number of patients, uncontrolled study and lack of long-term follow-up data are the limitations of the study.
  - 4,150 112
CASE REPORTS
Peculiar acral and oral pigmentation after docetaxel therapy: An unresolved dilemma
Guneet Awal, Tanreet Kaur
January-June 2018, 4(1):26-28
DOI:10.4103/ijdd.ijdd_9_18  
Taxanes, which are widely used chemotherapeutic agents for treating breast carcinoma, are known to cause various cutaneous side effects with incidence as high as 65%. These cutaneous manifestations range from minor nonspecific dermatological manifestations to perplexing atypical manifestations of classic entities such as hand-foot syndrome. We report a case of 51-year-old previously healthy postmenopausal woman diagnosed with T1N1M0 adenocarcinoma breast, on docetaxel adjuvant chemotherapy, who developed peculiar oral and acral violaceous hyperpigmentation. Recognition of this type of presentation as part of HFS or a separate entity is still a debatable conundrum.
  - 3,860 55
LETTERS TO EDITOR
Successful use of plasmapheresis as an adjuvant therapy in phenytoin induced toxic epidermal necrolysis
Vasudha V Sardesai, Sahil G Moriwala, Vidyadhar R Sardesai
January-June 2018, 4(1):31-32
DOI:10.4103/ijdd.ijdd_13_18  
  - 2,984 55
A rare case of rifampicin-induced urticaria confirmed by drug provocation test
Satyendra Kumar Singh, Bandana Jha
January-June 2018, 4(1):32-34
DOI:10.4103/ijdd.ijdd_1_18  
  - 5,717 77
Combination of 308 nm excimer light with topical tacalcitol ointment for vitiligo treatment
Kiran Godse, Gauri Godse
January-June 2018, 4(1):36-37
DOI:10.4103/ijdd.ijdd_15_18  
  - 3,790 93
Bullous fixed drug eruption due to diclofenac
Pendota Srihitha, Surabhineni Sre Akshaya Kalyani
January-June 2018, 4(1):37-38
DOI:10.4103/ijdd.ijdd_27_17  
  - 3,323 59
MANAGING A SIDE EFFECT
Managing a side effect: Cyclosporine-Induced nephrotoxicity
Manasi Shirolikar, Sushil Pande, Milind Borkar, Sachin Soni
January-June 2018, 4(1):39-44
DOI:10.4103/ijdd.ijdd_17_18  
  - 13,997 477
ORIGINAL ARTICLES
Comparision of oral levofloxacin and minocycline in treatment of inflammatory acne vulgaris: A randomized control trial
Swapna Khatu Sheth, Ankita Mundada, Neeta Gokhale, Pradeep Mahajan
January-June 2018, 4(1):7-12
DOI:10.4103/ijdd.ijdd_21_17  
Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous units. This disease occurs worldwide and usually starts in adolescence and resolves by mid-twenties. It is the most common skin disorder, and different studies have shown prevalence rates ranging from 28.9% to 91.3% in adolescents. Aims: The aim of this study is to assess, compare, and correlate therapeutic efficacy of oral levofloxacin and minocycline combine with benzoyl peroxide gel in the treatment of acne vulgaris. Methods: The study comprised 60 acne vulgaris patients. They were allotted randomly in two groups, 30 in each group. Baseline investigations were performed at 1st visit. Baseline photographs were taken. Levofloxacin was given at dose of 500 mg/day for 30 days along with topical benzoyl peroxide gel in one group, and another group received minocycline 100 mg for 3 months along with topical benzoyl peroxide gel. Results were assessed at 2, 4, 8, and 12 weeks after starting treatment according to the global acne grading system and compared with each other statistically using t-test. Results: There was a significant decrease in acne score in levofloxacin group as compared to minocycline group. (P = 0.05) at 4 weeks. At 8 weeks and 12 weeks, decrease in the score was more in minocycline group (P < 0.024) and (P < 0.001), respectively. According to the percentage of decrease in inflammatory count from baseline, there was a decrease in inflammatory lesion count by 58% at 4 weeks which increased to 81.1% at the end of 12 weeks in levofloxacin group. In minocycline group, a decrease in inflammatory lesion count at 4 weeks was 36.6% and 12 weeks was 68%.
  - 10,288 199
WHATS IN NEWS
News from regulatory corner: Safety communication and recent drug approvals
Pugazhenthan Thangaraju, Sajitha Venkatesan
January-June 2018, 4(1):45-46
DOI:10.4103/ijdd.ijdd_3_18  
  - 2,829 87